Trim33^tm1Los
Targeted Allele Detail

Summary

• Symbol: Trim33^tm1Los
• Name: tripartite motif-containing 33; targeted mutation 1, Regine Losson
• MGI ID: MGI:4355864
• Synonyms: Tif1gamma^lox, Trim33^tm1Ros
• Gene: Trim33 Location: Chr3:103186609-103266086 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Trim33^tm1Los page

Pancreatic tumors in Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0 and Kras^tm4Tyj/Kras^tm4Tyj Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149449
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed pgk-neo cassette was inserted into intron 1 and a third loxP site was inserted into intron 4 via homologous recombination. (J:149449, J:163858)

Tumor Data

List all tumor models in MMHCdb carrying Trim33^tm1Los

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim33 Mutation: 71 strains or lines available

References

• Original: J:149449 Doisne JM, et al., iNKT cell development is orchestrated by different branches of TGF-beta signaling. J Exp Med. 2009 Jun 8;206(6):1365-78
• All: 9 reference(s)