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Targeted Allele Detail
Symbol: Trim33tm1Los
Name: tripartite motif-containing 33; targeted mutation 1, Regine Losson
MGI ID: MGI:4355864
Synonyms: Tif1gammalox, Trim33tm1Ros
Gene: Trim33  Location: Chr3:103279293-103358770 bp, + strand  Genetic Position: Chr3, 45.25 cM
Pancreatic tumors in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 and Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:149449
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed pgk-neo cassette was inserted into intron 1 and a third loxP site was inserted into intron 4 via homologous recombination. (J:149449, J:163858)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim33 Mutation:  49 strains or lines available
Original:  J:149449 Doisne JM, et al., iNKT cell development is orchestrated by different branches of TGF-beta signaling. J Exp Med. 2009 Jun 8;206(6):1365-78
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory