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Targeted Allele Detail
Symbol: Ikzf2tm1Kast
Name: IKAROS family zinc finger 2; targeted mutation 1, Philippe Kastner
MGI ID: MGI:4355173
Synonyms: Helios-
Gene: Ikzf2  Location: Chr1:69531214-69687245 bp, - strand  Genetic Position: Chr1, 34.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:151553
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin cassette replaced the segment of exon 7 that lies between SalI and XbaI restriction sites. This mutation deleted sequences that encode the C-terminal zinc finger domains. The locus produced truncated mRNA as determined by RT-PCR. No protein was detected in immunoblot analysis of homozygote thymus extracts using an antibody specific to the N-terminal of the protein. (J:151553)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf2 Mutation:  11 strains or lines available
Original:  J:151553 Cai Q, et al., Helios deficiency has minimal impact on T cell development and function. J Immunol. 2009 Aug 15;183(4):2303-11
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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