About   Help   FAQ
Ikzf2tm1Kast
Targeted Allele Detail
Nomenclature
Symbol: Ikzf2tm1Kast
Name: IKAROS family zinc finger 2; targeted mutation 1, Philippe Kastner
MGI ID: MGI:4355173
Synonyms: Helios-
Gene: Ikzf2  Location: Chr1:69531214-69687245 bp, - strand  Genetic Position: Chr1, 34.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151553
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin cassette replaced the segment of exon 7 that lies between SalI and XbaI restriction sites. This mutation deleted sequences that encode the C-terminal zinc finger domains. The locus produced truncated mRNA as determined by RT-PCR. No protein was detected in immunoblot analysis of homozygote thymus extracts using an antibody specific to the N-terminal of the protein. (J:151553)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf2 Mutation:  12 strains or lines available
References
Original:  J:151553 Cai Q, et al., Helios deficiency has minimal impact on T cell development and function. J Immunol. 2009 Aug 15;183(4):2303-11
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/17/2017
MGI 6.10
The Jackson Laboratory