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Dlg1tm1.2Agri
Targeted Allele Detail
Nomenclature
Symbol: Dlg1tm1.2Agri
Name: discs, large homolog 1 (Drosophila); targeted mutation 1.2, Anne Griep
MGI ID: MGI:4354833
Synonyms: Dlg-1-
Gene: Dlg1  Location: Chr16:31663443-31873350 bp, + strand  Genetic Position: Chr16, 22.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151538
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsdownstream of exon 8 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 8. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:151538)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlg1 Mutation:  52 strains or lines available
References
Original:  J:151538 Rivera C, et al., Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis. Dev Dyn. 2009 Jul 21;238(9):2292-2308
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory