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Tg(Tyr-BRAF*V600E)476Fgh
Transgene Detail
Summary
Symbol: Tg(Tyr-BRAF*V600E)476Fgh
Name: transgene insertion 476, Frank G Haluska
MGI ID: MGI:4354193
Transgene: Tg(Tyr-BRAF*V600E)476Fgh  Location: unknown  
Alliance: Tg(Tyr-BRAF*V600E)476Fgh page
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tyr-BRAF*V600E)476Fgh expresses 1 gene
 
Mutation detailsThe mouse promoter was used to drive melanocyte-specific expression of the human cDNA containing the amino acid substitution of glutamic acid for valine at position 600 (V600E). This cDNA was cloned from a melanoma line. Four founders were generated and two lines examined (470 and 476). Line 470 exhibits a 3-fold high transcript expression compared to line 476. (J:151455)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:151455 Goel VK, et al., Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene. 2009 Jun 11;28(23):2289-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory