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Transgene Detail
Symbol: Tg(Ckm-GSN*D187N)AJewe
Name: transgene insertion A, Jeffery W Kelly
MGI ID: MGI:4353799
Transgene: Tg(Ckm-GSN*D187N)AJewe  Location: unknown  
Muscle of Tg(Ckm-GSN*D187N)AJewe/0 mice exhibit extensive amyloidogenesis

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Ckm-GSN*D187N)AJewe expresses 1 gene
Mutation detailsThe mouse promoter was used to drive muscle-specific expression of a human cDNA with mutations that result in an amino acid substitution of asparagine for aspartic acid at position 187 (D187N). This mutation was identified in patients with familial amyloidosis of Finnish type (FAF). Two lines were created (A and B). Line B exhibits sex-linked inheritance. (J:150825)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:150825 Page LJ, et al., Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11125-30
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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