Themis^tm1Lov
Targeted Allele Detail

Summary

• Symbol: Themis^tm1Lov
• Name: thymocyte selection associated; targeted mutation 1, Paul E Love
• MGI ID: MGI:4353254
• Synonyms: Themis1^-
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^tm1Lov page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151075
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exon 1 of the locus. Gene inactivation was confirmed by a lack detectable protein product in immunoblot analysis of homozygote thymocyte extracts. (J:151075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 55 strains or lines available

References

• Original: J:151075 Lesourne R, et al., Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009 Aug;10(8):840-7
• All: 8 reference(s)