Senp1^tm1.1Wami
Targeted Allele Detail

Summary

• Symbol: Senp1^tm1.1Wami
• Name: SUMO1/sentrin specific peptidase 1; targeted mutation 1.1, Wang Min
• MGI ID: MGI:4353110
• Gene: Senp1 Location: Chr15:97936625-97991625 bp, - strand Genetic Position: Chr15, 54.04 cM
• Alliance: Senp1^tm1.1Wami page

Erythropoietic defects in fetal liver of Senp1^tm1.1Wami/Senp1^tm1.1Wami mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination removes exons 5 and 6 along with the neo cassette.The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:150995)

Generation of the Senp1^tm1.1Wami allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp1 Mutation: 65 strains or lines available

References

• Original: J:150995 Li X, et al., SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ. 2008 Apr;15(4):739-50
• All: 3 reference(s)