About   Help   FAQ
Themistm1Gasc
Targeted Allele Detail
Nomenclature
Symbol: Themistm1Gasc
Name: thymocyte selection associated; targeted mutation 1, Nicholas R J Gascoigne
MGI ID: MGI:4353091
Synonyms: Themis-
Gene: Themis  Location: Chr10:28668360-28883818 bp, + strand  Genetic Position: Chr10, 16.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151074
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exon 1 of the gene locus. Gene inactivation was confirmed by a lack of protein detected in immunoblot assays of homozygote thymus extract. (J:151074)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Themis Mutation:  21 strains or lines available
References
Original:  J:151074 Fu G, et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009 Aug;10(8):848-56
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory