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Themistm1Gasc
Targeted Allele Detail
Nomenclature
Symbol: Themistm1Gasc
Name: thymocyte selection associated; targeted mutation 1, Nicholas R J Gascoigne
MGI ID: MGI:4353091
Synonyms: Themis-
Gene: Themis  Location: Chr10:28668360-28883818 bp, + strand  Genetic Position: Chr10, 16.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151074
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exon 1 of the gene locus. Gene inactivation was confirmed by a lack of protein detected in immunoblot assays of homozygote thymus extract. (J:151074)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Themis Mutation:  15 strains or lines available
References
Original:  J:151074 Fu G, et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009 Aug;10(8):848-56
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory