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Targeted Allele Detail
Symbol: Antxr2tm1.2Lepp
Name: anthrax toxin receptor 2; targeted mutation 1.2, Stephen H Leppla
MGI ID: MGI:4352944
Synonyms: CMG2-
Gene: Antxr2  Location: Chr5:97884688-98031017 bp, - strand  Genetic Position: Chr5, 47.77 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:150952
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 12, which encodes the transmembrane domain, and an frt flanked neo cassette and second loxP site were inserted downstream of exon 12. Cre mediated recombination then removed exon 12 and (when present) the neo cassette leaving behind a single loxP site. (J:150952)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Antxr2 Mutation:  3 strains or lines available
Original:  J:150952 Liu S, et al., Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory