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Antxr1tm1.2Lepp
Targeted Allele Detail
Nomenclature
Symbol: Antxr1tm1.2Lepp
Name: anthrax toxin receptor 1; targeted mutation 1.2, Stephen H Leppla
MGI ID: MGI:4352941
Synonyms: TEM8-
Gene: Antxr1  Location: Chr6:87133853-87335809 bp, - strand  Genetic Position: Chr6, 37.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150952
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 13, which encodes the transmembrane domain, and an frt flanked neo cassette and second loxP site were inserted downstream of exon 13. Cre mediated recombination then removed exon 13 l and (when present) the neo cassette leaving behind a single loxP site. Western blot analysis confirmed the absence of protein expression in lysates from homozygous MEFs but a mutant protein was detected in conditioned media from homozygous MEFs. (J:150952)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Antxr1 Mutation:  4 strains or lines available
References
Original:  J:150952 Liu S, et al., Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory