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Appl1Gt(RRS819)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Appl1Gt(RRS819)Byg
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; gene trap RRS819, BayGenomics
MGI ID: MGI:4332126
Gene: Appl1  Location: Chr14:26918986-26970611 bp, - strand  Genetic Position: Chr14, 16.09 cM, cytoband B
Mutation
origin
Mutant Cell Line:  RRS819
Germline Transmission:  Earliest citation of germline transmission: J:211794
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector, pGTxf, which contains a splice acceptor-beta geo cassette-polyadenylation sequence, was inserted between exon 7 and exon 8. The insertion results in the disruption of the gene transcription and expression. Western blot analysis confirmed absence of protein expression in liver, fat, and skeletal muscle tissue homogenates from homozygous mutant mice. (J:211794)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Appl1 Mutation:  3 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory