Vps35^{Gt(RRK261)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Vps35^{Gt(RRK261)Byg}
• Name: VPS35 retromer complex component; gene trap RRK261, BayGenomics
• MGI ID: MGI:4130266
• Synonyms: Vps35^m
• Gene: Vps35 Location: Chr8:85987014-86026146 bp, - strand Genetic Position: Chr8, 41.61 cM
• Alliance: Vps35^{Gt(RRK261)Byg} page

Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35^{Gt(RRK261)Byg}/Vps35⁺ Tg(APPSWE)2576Kha/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: RRK261
• Germline Transmission: Earliest citation of germline transmission: J:178937
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• The gene trap vector inserted into intron 13. (J:178937)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRK261	CC894064 ; (MGI Seq Detail)	5' RACE	Chr8:85997322-86000258 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Vps35^{Gt(RRK261)Byg} allele

Disease models

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vps35 Mutation: 44 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 11 reference(s)