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Pofut2Gt(RST434)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Pofut2Gt(RST434)Byg
Name: protein O-fucosyltransferase 2; gene trap RST434, BayGenomics
MGI ID: MGI:4127173
Synonyms: RST434
Gene: Pofut2  Location: Chr10:77095052-77105409 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Mutant Cell Line:  RST434
Germline Transmission:  Earliest citation of germline transmission: J:165751
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0TMpfs     Vector Type: secretory trap
 
Mutation detailsA gene trap vector insertion occurred within exon 6 and resulted in an inframe fusion between Pofut2 (exons 1 through 5) and beta-gal-neomycin. The resulting fusion protein lack TSR-specific O-fucosyltransferase activity. It is a null allele. (J:165751)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 72 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pofut2 Mutation:  19 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory