About   Help   FAQ
PpibGt(RST139)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: PpibGt(RST139)Byg
Name: peptidylprolyl isomerase B; gene trap RST139, BayGenomics
MGI ID: MGI:4125284
Synonyms: PpibGT
Gene: Ppib  Location: Chr9:66060222-66066623 bp, + strand  Genetic Position: Chr9, 35.69 cM
Mutation
origin
Mutant Cell Line:  RST139
Germline Transmission:  Earliest citation of germline transmission: J:226318
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0TMpfs     Vector Type: secretory trap
 
Mutation detailsThe gene trap construct inserted into intron 1 and consisted of a splice acceptor sequence from the mouse En2 gene, followed by a beta-galactosidase/neomycin (beta-geo) reporter-selection cassette and SV40 polyadenylation signal. The insertion of the gene trap vector inserted 123 bp from the 5-end of the 1066 bp intron 1. The insertional mutation interrupts transcription of the gene in cells and tissues isolated from homozygous mutant mice. Expression of the gene was reduced in cells and tissues heterozygous for the gene-trapped allele, and completely absent from homozygous cells and tissues. (J:226318)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppib Mutation:  4 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory