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Casz1Gt(CJ0565)Wtsi
Gene trapped Allele Detail
Nomenclature
Symbol: Casz1Gt(CJ0565)Wtsi
Name: castor zinc finger 1; gene trap CJ0565, Wellcome Trust Sanger Institute
MGI ID: MGI:3870873
Synonyms: Casz1betageo
Gene: Casz1  Location: Chr4:148804429-148954889 bp, + strand  Genetic Position: Chr4, 78.87 cM
Edema, heart failure, and heart abnormalities in E16.5 Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi fetuses

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  CJ0565
Germline Transmission:  Earliest citation of germline transmission: J:242127
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Sanger Inst. Gene Trap Res.
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0lxrT2
 
Mutation detailsA gene trap containing a beta-geo reporter inserted into the sequences after exon 9, resulting in a truncated protein in which 10 of the 11 zinc fingers are lost. Real time PCR analysis revealed no detectable mRNA in the heart of E12.5 homozygous mutant embryos. Western blot analysis confirmed the absence of protein expression of both the full-length (Casz1a) and shorter (Casz1b) isoform in E14.5 whole heart lysates. (J:242127)
Sequence Tags: 
Sequence tag details (1 tag)
Generation of the Casz1Gt(CJ0565)Wtsi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casz1 Mutation:  283 strains or lines available
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory