Ndufs4^{Gt(CB0524)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Ndufs4^{Gt(CB0524)Wtsi}
• Name: NADH:ubiquinone oxidoreductase core subunit S4; gene trap CB0524, Wellcome Trust Sanger Institute
• MGI ID: MGI:3866986
• Synonyms: Ndufs4^CB0524, Ndufs4^GT
• Gene: Ndufs4 Location: Chr13:114424331-114524630 bp, - strand Genetic Position: Chr13, 64.12 cM, cytoband D2.2
• Alliance: Ndufs4^{Gt(CB0524)Wtsi} page

Mutation origin

• Mutant Cell Line: CB0524
• Germline Transmission: Earliest citation of germline transmission: J:326310
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion Vector: pGT0lxfT1
• Mutation details: A gene trap vector inserted into intron 1. A 50% reduction in both encoded mRNA transcript, as well as encoded protein abundance was shown in brain tissue of homozygous mice, resulting in a 25% reduction in protein activity in the hippocampus compared to controls. (J:326310)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  CB0524	CZ444367 ; (MGI Seq Detail)	5' RACE	Chr13:114524494-114524613 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  38 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndufs4 Mutation: 27 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 2 reference(s)