Sox17tm1(icre)Heli
Targeted Allele Detail
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Symbol: |
Sox17tm1(icre)Heli |
Name: |
SRY (sex determining region Y)-box 17; targeted mutation 1, Heiko Lickert |
MGI ID: |
MGI:3852645 |
Synonyms: |
Sox17iCre, Sox17iCredeltaneo, Sox17tm1(icre)Lic |
Gene: |
Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
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Alliance: |
Sox17tm1(icre)Heli page
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Germline Transmission: |
Earliest citation of germline transmission:
J:150862
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Parent Cell Line: |
TBV2 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Sox17tm1(icre)Heli expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Sox17 (MGI:107543) |
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Mutation details: A targeting vector containing a mini gene locus with a codon improved cre recombinase cDNA with a translational stop codo, splice donor site, artificial intron and an exon encoding the SV40 polyadenylation signal followed by an FRT-flanked PGK-neo cassette in the opposite orientation was introduced into exon 1 of Sox17 by homologous recombination in TBV2 ES cells. Germline chimeras were generated and the neo cassette was excised by crossing these with Flpe mice.
(J:150862)
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Generation of the Sox17tm1(icre)Heli allele |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Sox17
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sox17 Mutation: |
28 strains or lines available
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Original: |
J:150862 Liao WP, et al., Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries. Genesis. 2009 Jul;47(7):476-83 |
All: |
3 reference(s) |
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