Tg(Myh6/NFAT-luc)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/NFAT-luc)1Jmol
• Name: transgene insertion 1, Jeffery D Molkentin
• MGI ID: MGI:3851596
• Synonyms: NFAT-luc, Tg(NFAT luc reporter)
• Transgene: Tg(Myh6/NFAT-luc)1Jmol Location: unknown
• Alliance: Tg(Myh6/NFAT-luc)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Nine copies of a nuclear factor of activated T cell (NFAT) binding site (5'-TGGAAAATT-3') from the interleukin 4 (Il4) promoter were placed 5' to a mouse alpha myosin heavy chain (Myh6) and upstream of a luciferase promoter. (J:83547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:83547 Braz JC, et al., Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest. 2003 May;111(10):1475-86
• All: 19 reference(s)