Acsbg1^tm1Mld
Targeted Allele Detail

Summary

• Symbol: Acsbg1^tm1Mld
• Name: acyl-CoA synthetase bubblegum family member 1; targeted mutation 1, Maria L Dufau
• MGI ID: MGI:3851593
• Gene: Acsbg1 Location: Chr9:54512161-54569154 bp, - strand Genetic Position: Chr9, 29.7 cM
• Alliance: Acsbg1^tm1Mld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150391
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment including exons 1 and 2 was replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in testis from homozygous mice. Western blot analysis confirmed the absence of protein expression in the testis, ovary, adrenal gland, and brain from homozygous mice. (J:150391)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acsbg1 Mutation: 35 strains or lines available

References

• Original: J:150391 Sheng Y, et al., Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):44-56
• All: 1 reference(s)