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Targeted Allele Detail
Symbol: Acsbg1tm1Mld
Name: acyl-CoA synthetase bubblegum family member 1; targeted mutation 1, Maria L Dufau
MGI ID: MGI:3851593
Gene: Acsbg1  Location: Chr9:54604877-54661870 bp, - strand  Genetic Position: Chr9, 29.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:150391
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment including exons 1 and 2 was replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in testis from homozygous mice. Western blot analysis confirmed the absence of protein expression in the testis, ovary, adrenal gland, and brain from homozygous mice. (J:150391)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acsbg1 Mutation:  20 strains or lines available
Original:  J:150391 Sheng Y, et al., Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):44-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory