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Tg(Myh6/tetO-PRKCA*)1Jmk
Transgene Detail
Nomenclature
Symbol: Tg(Myh6/tetO-PRKCA*)1Jmk
Name: transgene insertion 1, Jeffery D Molkentin
MGI ID: MGI:3851565
Synonyms: dnPrkca, Tg(dnPrkca)
Transgene: Tg(Myh6/tetO-PRKCA*)1Jmk  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6/tetO-PRKCA*)1Jmk expresses 1 gene
 
Mutation detailsThe rabbit PRKCA cDNA carrying the dominant negative L368A mutation was fused to the cardiac-specific alpha myosin heavy chain (Myh6) mouse promoter. The promoter is minimally active/attenuated through the ablation of three GATA sites and two thyroid-like response elements. Seven copies of tetracycline-responsive promoter element (tetO) are fused to the promoter. (J:88510, J:132098)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:132098 Hambleton M, et al., Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3768-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory