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Efnb3tm3.1Henk
Targeted Allele Detail
Summary
Symbol: Efnb3tm3.1Henk
Name: ephrin B3; targeted mutation 3.1, Mark Henkemyer
MGI ID: MGI:3851478
Synonyms: Efnb35F
Gene: Efnb3  Location: Chr11:69444918-69451031 bp, - strand  Genetic Position: Chr11, 42.8 cM
Alliance: Efnb3tm3.1Henk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150550
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitutions in exon 5 replace five tyrosines with phenylalanine at positions 311, 318, 323, 337, and 338 (p.Y311F, p.Y318F, p.Y323F, p.(Y337_Y338delinsFF)). A loxP site flanked neomycin resistance gene cassette that was inserted into intron 4 was removed through subsequent cre-mediated recombination. (J:150550)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Efnb3 Mutation:  11 strains or lines available
References
Original:  J:150550 Xu NJ, et al., Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning. Nat Neurosci. 2009 Mar;12(3):268-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory