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Tg(Cd4-Maf)6666Glm
Transgene Detail
Nomenclature
Symbol: Tg(Cd4-Maf)6666Glm
Name: transgene insertion 6666, Laurie H Glimcher
MGI ID: MGI:3851458
Synonyms: 6666, mafTG
Transgene: Tg(Cd4-Maf)6666Glm  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA 4-kb full length cDNA encoding the c-maf (Maf) gene was cloned into a vector containing the Cd4 promoter-enhancer and first intron without the silencer element. This construct was injected into C57BL/6 blastocysts. 6 founders were obtained and three low copy number transgenics transmitted the transgene to progeny. Lines 6666 (with moderately high levels of Maf tg mRNA in thymus and low levels in spleen) and 6272 (with very low levels of Maf transgenic mRNA in thymus and spleen) were characterized further (J:95878)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:94878 Ho IC, et al., c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J Exp Med. 1998 Nov 16;188(10):1859-66
All:  5 reference(s)

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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory