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Rfx4Tg(Myh6-CYP2J2)Tr5Dcz
Transgenic Allele Detail
Summary
Symbol: Rfx4Tg(Myh6-CYP2J2)Tr5Dcz
Name: regulatory factor X, 4 (influences HLA class II expression); transgene insertion Tr5, Darryl Zeldin
MGI ID: MGI:3851404
Gene: Rfx4  Location: Chr10:84591926-84742402 bp, + strand  Genetic Position: Chr10, 41.63 cM, cytoband C1
Alliance: Rfx4Tg(Myh6-CYP2J2)Tr5Dcz page
Transgene
origin
Strain of Origin:  C57BL/6NTac
Transgene
description
Transgene Type:    Transgenic (Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsTwo tandem copies of concatenated transgene consisting of human CYP2J2 cDNA with mouse alpha-MHC promoter and human growth hormone intron and polyA sequence was inserted into intron of mouse Rfx4 gene. This transgene is one of six lines described in J:101489. Northern blot analysis revealed that variant form of the transcript RFX4_v3 expression was absent in brain whereas other two forms, variant 1 and 2, expression were not affected. This is an isoform specific null allele. (J:84751)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rfx4 Mutation:  48 strains or lines available
References
Original:  J:84751 Blackshear PJ, et al., Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development. 2003 Oct;130(19):4539-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory