About   Help   FAQ
Tg(Mt1-CBS*S466L)EB86Waku
Transgene Detail
Nomenclature
Symbol: Tg(Mt1-CBS*S466L)EB86Waku
Name: transgene insertion EB86, Warren Kruger
MGI ID: MGI:3851386
Synonyms: Tg-S466L
Transgene: Tg(Mt1-CBS*S466L)EB86Waku  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe mouse promoter was used to drive zinc-inducible expression of the human cDNA with a point mutation that results in the amino acid substitution of lysine for serine at position 466. This mutation was identified in patients with homocystinuria. Three lines were created and line EB86 was selected as the representative line. (J:150703)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:150703 Gupta S, et al., Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice. Hum Mutat. 2008 Aug;29(8):1048-54
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory