Batf^tm1.1Kmm
Targeted Allele Detail

Summary

• Symbol: Batf^tm1.1Kmm
• Name: basic leucine zipper transcription factor, ATF-like; targeted mutation 1.1, Kenneth M Murphy
• MGI ID: MGI:3851385
• Gene: Batf Location: Chr12:85733494-85755861 bp, + strand Genetic Position: Chr12, 39.78 cM
• Alliance: Batf^tm1.1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150643
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a floxed neomycin cassette. The neomycin cassette was subsequently removed by transient expression of cre recombinase. No protein product was detected by immunoblot analysis of homozygote splenocyte or Th17 cells. (J:150643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Batf Mutation: 14 strains or lines available

References

• Original: J:150643 Schraml BU, et al., The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009 Jul 16;460(7253):405-9
• All: 32 reference(s)