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Batftm1.1Kmm
Targeted Allele Detail
Nomenclature
Symbol: Batftm1.1Kmm
Name: basic leucine zipper transcription factor, ATF-like; targeted mutation 1.1, Kenneth M Murphy
MGI ID: MGI:3851385
Gene: Batf  Location: Chr12:85686669-85709087 bp, + strand  Genetic Position: Chr12, 39.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150643
Parent Cell Line:  EDJ22 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a floxed neomycin cassette. The neomycin cassette was subsequently removed by transient expression of cre recombinase. No protein product was detected by immunoblot analysis of homozygote splenocyte or Th17 cells. (J:150643)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Batf Mutation:  10 strains or lines available
References
Original:  J:150643 Schraml BU, et al., The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009 Jul 16;460(7253):405-9
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory