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Tph2tm1.2Kpl
Targeted Allele Detail
Nomenclature
Symbol: Tph2tm1.2Kpl
Name: tryptophan hydroxylase 2; targeted mutation 1.2, Klaus-Peter Lesch
MGI ID: MGI:3851254
Gene: Tph2  Location: Chr10:115078641-115185022 bp, - strand  Genetic Position: Chr10, 63.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150637
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Germ line, cre mediated recombination removed exon 5. (J:150637)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:  15 strains or lines available
References
Original:  J:150637 Gutknecht L, et al., Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm. 2008 Aug;115(8):1127-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory