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Treml1tm1Mcvic
Targeted Allele Detail
Nomenclature
Symbol: Treml1tm1Mcvic
Name: triggering receptor expressed on myeloid cells-like 1; targeted mutation 1, Daniel W McVicar
MGI ID: MGI:3851246
Synonyms: Tlt1-
Gene: Treml1  Location: Chr17:48359916-48367174 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Increased hemorrhage associated with inflammation in Treml1tm1Mcvic/Treml1tm1Mcvic mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150578
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a floxed neomycin cassette. The absence of the protein was determined by Western blot and confocal analysis on homozygote tissues (J:150578)
Generation of the Treml1tm1Mcvic allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Treml1 Mutation:  12 strains or lines available
References
Original:  J:150578 Washington AV, et al., TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest. 2009 Jun;119(6):1489-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory