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Targeted Allele Detail
Symbol: Treml1tm1Mcvic
Name: triggering receptor expressed on myeloid cells-like 1; targeted mutation 1, Daniel W McVicar
MGI ID: MGI:3851246
Synonyms: Tlt1-
Gene: Treml1  Location: Chr17:48359916-48367176 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Increased hemorrhage associated with inflammation in Treml1tm1Mcvic/Treml1tm1Mcvic mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:150578
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a floxed neomycin cassette. The absence of the protein was determined by Western blot and confocal analysis on homozygote tissues (J:150578)
Generation of the Treml1tm1Mcvic allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Treml1 Mutation:  15 strains or lines available
Original:  J:150578 Washington AV, et al., TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest. 2009 Jun;119(6):1489-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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