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Tg(Kera-PITX2*A)AHjal
Transgene Detail
Nomenclature
Symbol: Tg(Kera-PITX2*A)AHjal
Name: transgene insertion A, Tord Hjalt
MGI ID: MGI:3851135
Synonyms: Ktcn-PITX2, Tg(Kera-PITX2*A)3Hjal
Transgene: Tg(Kera-PITX2*A)AHjal  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Kera-PITX2*A)AHjal expresses 1 gene
 
Mutation detailsA transgenic construct containing cDNA for the human paired-like homeodomain 2, human, PITX2, A isoform, under the control of the mouse keratocan (Kera) promoter, and rabbit beta-globin polyA signal sequences was injected into fertilized CBAB6F2 mouse eggs. Numerous founders were obtained. In line A, multiple copies were found to be integrated into chromosome 10B1. Lines A and B display identical phenotypes. (J:93634)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:93634 Holmberg J, et al., PITX2 gain-of-function in rieger syndrome eye model. Am J Pathol. 2004 Nov;165(5):1633-41
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory