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Targeted Allele Detail
Symbol: Foxp2tm2.1Woen
Name: forkhead box P2; targeted mutation 2.1, Wolfgang Enard
MGI ID: MGI:3851122
Synonyms: Foxp2hum, Foxp2humdeltaneo
Gene: Foxp2  Location: Chr6:14901388-15441201 bp, + strand  Genetic Position: Chr6, 6.49 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:150425
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 7 was replaced with a frt flanked neo cassette with a 5' loxP site and a modified exon 7 followed by a 3' loxP site. The modified exon 7 contains nucleotide substitutions that result in two amino acid substitutions, namely, asparagine for threonine at position 302 (T302N), and serine for asparagine at position 324 (N324S). These amino acid substitutions mimic the amino acids found in humans. Germ line, flp mediated recombination removed the neo cassette leaving exon 7 floxed. (J:150425)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp2 Mutation:  28 strains or lines available
Original:  J:150425 Enard W, et al., A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 May 29;137(5):961-71
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory