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Targeted Allele Detail
Symbol: Ightm2.1(Tag)Rwhe
Name: immunoglobulin heavy chain complex; targeted mutation 2.1, Rudolf Hendriks
MGI ID: MGI:3850723
Synonyms: IgH.TEmu
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:150315
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA floxed neomycin resistance gene, a splice accepter, an internal ribosome entry site, a SV40 large and small T antigen coding region, and an extra copy of the IgH intronic enhancer Emu were inserted in a reverse orientation between DQ52 and JH1 in the IgH locus. The neomycin gene was removed after targeting by crossing founder mice with transgenic mice expressing cre in the germline. SV40 T antigen transcripts were detected by RT-PCR in B cells. (J:150315)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
Original:  J:150315 ter Brugge PJ, et al., A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood. 2009 Jul 2;114(1):119-27
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory