About   Help   FAQ
Ightm1.1(Tag)Rwhe
Targeted Allele Detail
Nomenclature
Symbol: Ightm1.1(Tag)Rwhe
Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Rudolf Hendriks
MGI ID: MGI:3850722
Synonyms: IgH.T
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150315
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin resistance gene, a splice accepter, an internal ribosome entry site, and a SV40 large and small T antigen coding region were inserted in a reverse orientation between DQ52 and JH1 in the IgH locus. The neomycin gene was removed after targeting by crossing founder mice with transgenic mice expressing cre in the germline. SV40 T antigen transcripts were detected by RT-PCR in B cells. (J:150315)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:150315 ter Brugge PJ, et al., A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood. 2009 Jul 2;114(1):119-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2022
MGI 6.19
The Jackson Laboratory