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Targeted Allele Detail
Symbol: Pink1tm1Aub
Name: PTEN induced putative kinase 1; targeted mutation 1, Georg Auburger
MGI ID: MGI:3850370
Gene: Pink1  Location: Chr4:138313409-138326307 bp, - strand  Genetic Position: Chr4, 70.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:150206
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
Mutation detailsA G309D (g8343a) mutation was inserted in exon 4 and a floxed neo cassette in inverse orientation was inserted into intron 5 via homologous recombination. Northern blot and saturation RT-PCR of splice boundaries in brain and liver mRNA analysis confirmed the absence of full length transcript expression. Saturation RT-PCR also suggests the residual expression of low levels of a large mutant mRNA. (J:150206)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pink1 Mutation:  8 strains or lines available
Original:  J:150206 Gispert S, et al., Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One. 2009;4(6):e5777
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory