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Dicer1tm1.2Mnn
Targeted Allele Detail
Nomenclature
Symbol: Dicer1tm1.2Mnn
Name: dicer 1, ribonuclease type III; targeted mutation 1.2, Jeff Mann
MGI ID: MGI:3850193
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150221
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated reccombination removed exons 25 through 27. The absence of transcript expression was confirmed by RT-PCR analysis on oocyte extracts. (J:150221)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  58 strains or lines available
References
Original:  J:150221 Mattiske DM, et al., Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm. Reproduction. 2009 Apr;137(4):625-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory