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Clrn1tm1.1Kuna
Targeted Allele Detail
Nomenclature
Symbol: Clrn1tm1.1Kuna
Name: clarin 1; targeted mutation 1.1, Kumar N Alagramam
MGI ID: MGI:3850171
Gene: Clrn1  Location: Chr3:58844028-58885340 bp, - strand  Genetic Position: Chr3, 28.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150215
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination removes the neo cassette and exon 1. RT-PCR on P30 and P60 cochlear extracts confirmed the absence of transcript expression. (J:150215)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clrn1 Mutation:  8 strains or lines available
References
Original:  J:150215 Geng R, et al., Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 1;18(15):2748-60
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory