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Nlrp3tm1Wstr
Targeted Allele Detail
Nomenclature
Symbol: Nlrp3tm1Wstr
Name: NLR family, pyrin domain containing 3; targeted mutation 1, Warren Strober
MGI ID: MGI:3850069
Synonyms: Nlrp3R258W
Gene: Nlrp3  Location: Chr11:59541568-59566955 bp, + strand  Genetic Position: Chr11, 37.73 cM, cytoband B1.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp3 Mutation:  8 strains or lines available
References
Original:  J:150053 Meng G, et al., A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity. 2009 Jun 19;30(6):860-74
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory