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Erbintm1Line
Targeted Allele Detail
Nomenclature
Symbol: Erbintm1Line
Name: Erbb2 interacting protein; targeted mutation 1, Lin Mei
MGI ID: MGI:3849990
Synonyms: erbin-
Gene: Erbin  Location: Chr13:103818787-103920514 bp, - strand  Genetic Position: Chr13, 56.16 cM, cytoband D1
Hypomyelination and abnormal axonal segregation in Remak bundles of Erbintm1Line/Erbintm1Line sciatic nerves

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149996
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:149996)
Generation of the Erbintm1Line allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbin Mutation:  1 strain or line available
References
Original:  J:149996 Tao Y, et al., Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9477-82
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory