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Targeted Allele Detail
Symbol: Erbintm1Line
Name: Erbb2 interacting protein; targeted mutation 1, Lin Mei
MGI ID: MGI:3849990
Synonyms: erbin-
Gene: Erbin  Location: Chr13:103818787-103920514 bp, - strand  Genetic Position: Chr13, 56.16 cM, cytoband D1
Hypomyelination and abnormal axonal segregation in Remak bundles of Erbintm1Line/Erbintm1Line sciatic nerves

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:149996
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:149996)
Generation of the Erbintm1Line allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbin Mutation:  1 strain or line available
Original:  J:149996 Tao Y, et al., Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9477-82
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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