Glis3^tm1Hiha
Targeted Allele Detail

Summary

• Symbol: Glis3^tm1Hiha
• Name: GLIS family zinc finger 3; targeted mutation 1, Hisashi Hashimoto
• MGI ID: MGI:3849863
• Gene: Glis3 Location: Chr19:28236251-28657477 bp, - strand Genetic Position: Chr19, 22.88 cM
• Alliance: Glis3^tm1Hiha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150077
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5, which contains most of the zinc finger motifs, was replaced with a floxed pgk-neo cassette via homologous recombination. (J:150077)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glis3 Mutation: 40 strains or lines available

References

• Original: J:150077 Watanabe N, et al., A murine model of neonatal diabetes mellitus in Glis3-deficient mice. FEBS Lett. 2009 Jun 18;583(12):2108-13
• All: 2 reference(s)