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Targeted Allele Detail
Symbol: Tph2tm1Bdr
Name: tryptophan hydroxylase 2; targeted mutation 1, Michael Bader
MGI ID: MGI:3849838
Gene: Tph2  Location: Chr10:115078641-115185022 bp, - strand  Genetic Position: Chr10, 63.51 cM
Growth retardation and postnatal lethality in Tph2tm1Bdr/Tph2tm1Bdr mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:150042
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding region of exon 1 and exon 2 were replaced with a neo cassette. The absence of transcripts coding for exons 1 through 6 was confirmed by western blot analysis on brain extracts. (J:150042)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:  25 strains or lines available
Original:  J:150042 Alenina N, et al., Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10332-7
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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