Gpr68^tm1.1Yaxu
Targeted Allele Detail

Summary

• Symbol: Gpr68^tm1.1Yaxu
• Name: G protein-coupled receptor 68; targeted mutation 1.1, Yan Xu
• MGI ID: MGI:3849457
• Synonyms: OGR1^-
• Gene: Gpr68 Location: Chr12:100842941-100874457 bp, - strand Genetic Position: Chr12, 51.1 cM
• Alliance: Gpr68^tm1.1Yaxu page

Brown adipose tissue abnormality in Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu mice compared to Gpr68^tm1Yaxu/Gpr68^tm1Yaxu mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149315
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed the open reading frame. The absence of transcript expression was confirmed by RT-PCR on numerous tissue extracts. (J:149315)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr68 Mutation: 23 strains or lines available

References

• Original: J:149315 Li H, et al., Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One. 2009;4(5):e5705
• All: 9 reference(s)