B4galt2^tm1Masn
Targeted Allele Detail

Summary

• Symbol: B4galt2^tm1Masn
• Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2; targeted mutation 1, Masahide Asano
• MGI ID: MGI:3849305
• Synonyms: beta4GalT-II^-
• Gene: B4galt2 Location: Chr4:117730197-117740759 bp, - strand Genetic Position: Chr4, 53.7 cM, cytoband D1
• Alliance: B4galt2^tm1Masn page

Reduced cortex and enlargement of the lateral ventricle in B4galt2^tm1Masn/B4galt2^tm1Masn mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149762
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 and 2 and part of exon 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot and RT-PCR analysis on brain extracts. (J:149762)

Generation of the B4galt2^tm1Masn allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B4galt2 Mutation: 11 strains or lines available

References

• Original: J:149762 Yoshihara T, et al., Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. J Biol Chem. 2009 May 1;284(18):12550-61
• All: 1 reference(s)