Cdkn2a^tm1Sxs
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm1Sxs
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Stephen X Skapek
• MGI ID: MGI:3848992
• Synonyms: Arf^lacZ
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm1Sxs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149526
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon1b was replaced with a cassette containing lacZ and neo in opposite orientations. LacZ expression recapitulates endogenous gene expression in the eye and testis. (J:149526)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 62 strains or lines available

References

• Original: J:149526 Freeman-Anderson NE, et al., Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development. Development. 2009 Jun;136(12):2081-9
• All: 3 reference(s)