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Transgene Detail
Symbol: Tg(Mt1-LDLR)93-4Reh
Name: transgene insertion 93-4, Robert E Hammer
MGI ID: MGI:3848828
Synonyms: hLDLRTg, mMT-I-hLDLR-hGH
Transgene: Tg(Mt1-LDLR)93-4Reh  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Mt1-LDLR)93-4Reh expresses 1 gene
Mutation detailsTransgenic mice were created in the laboratory of Dr. Robert E Hammer (University of Texas Southwestern Medical Center). The MMT-I-hLDLR transgene was designed with a 1.7 kb fragment of mouse metallothionein 1 gene (Mt1) promoter, a 2.6 kb cDNA of the human low density lipoprotein receptor (hLDLR) complete coding region (and 27 basepairs of 5' UTR), and the transcription termination signal from the human growth hormone gene. This transgene was microinjected into the male pronuclei of fertilized (C57/SJL)F2 hybrid mouse eggs, Founder mouse 93-4, with high hLDLR expression in the liver, was bred to establish the colony. These mice have 3 copies of the transgene inserted at a single site and express human LDLR mRNA. (J:127519)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:127519 Hofmann SL, et al., Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science. 1988 Mar 11;239(4845):1277-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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