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Targeted Allele Detail
Symbol: Apctm1Ecrm
Name: adenomatosis polyposis coli; targeted mutation 1, Els C Robanus-Maandag
MGI ID: MGI:3848479
Synonyms: Apc15lox, Apcex15lox
Gene: Apc  Location: Chr18:34220924-34318608 bp, + strand  Genetic Position: Chr18, 18.53 cM
Skeletogenesis is severely impaired in Apctm1Ecrm/Apctm1Ecrm Tg(Col2a1-cre)1Rsjo/0 mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:149225
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted upstream of exon 15 and an additional loxP site was inserted downstream of exon 15. Cre mediated recombination removed the neo cassette leaving exon 15 floxed. (J:149225)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  85 strains or lines available
Original:  J:149225 Miclea RL, et al., Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009;9:26
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory