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Targeted Allele Detail
Symbol: Apctm1Rsmi
Name: APC, WNT signaling pathway regulator; targeted mutation 1, Ron Smits
MGI ID: MGI:3848479
Synonyms: Apc15lox, Apc16lox, Apcex15lox, Apctm1Ecrm
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Skeletogenesis is severely impaired in Apctm1Rsmi/Apctm1Rsmi Tg(Col2a1-cre)1Rsjo/0 mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:149225
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted upstream of exon 16 (formerly 15) and an additional loxP site was inserted downstream of exon 16. Cre mediated recombination removed the neo cassette leaving exon 16 floxed. (J:149225)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  119 strains or lines available
Original:  J:149225 Miclea RL, et al., Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009;9:26
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory