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Targeted Allele Detail
Symbol: Hsf4tm1Xyk
Name: heat shock transcription factor 4; targeted mutation 1, Xiangyin Kong
MGI ID: MGI:3848361
Gene: Hsf4  Location: Chr8:105269801-105275845 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Lens abnormalities and developmental defects in Hsf4tm1Xyk/Hsf4tm1Xyk mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:149354
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 3-5 were replaced with a PGK-neomycin resistance cassette. (J:149354)
Generation of the Hsf4tm1Xyk allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsf4 Mutation:  20 strains or lines available
Original:  J:149354 Shi X, et al., Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression. BMC Mol Biol. 2009;10:10
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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