Zbtb20^tm1.1Wpjz
Targeted Allele Detail

Summary

• Symbol: Zbtb20^tm1.1Wpjz
• Name: zinc finger and BTB domain containing 20; targeted mutation 1.1, Weiping J Zhang
• MGI ID: MGI:3848219
• Synonyms: Zbtb20^-
• Gene: Zbtb20 Location: Chr16:42728008-43462981 bp, + strand Genetic Position: Chr16, 28.44 cM, cytoband B4
• Alliance: Zbtb20^tm1.1Wpjz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148992
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: PC3 ES cells contain a protamine-cre transgene, Tg(Prm-cre)70Og, which expresses Cre recombinase under control of the male-germline specific protamine promoter. Cre-mediated excision removed exon 6 upon transmission from male chimeras. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:148992)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb20 Mutation: 55 strains or lines available

References

• Original: J:148992 Sutherland AP, et al., Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol. 2009 May;29(10):2804-15
• All: 6 reference(s)