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Akt3tm1Nhy
Targeted Allele Detail
Nomenclature
Symbol: Akt3tm1Nhy
Name: thymoma viral proto-oncogene 3; targeted mutation 1, Nissim Hay
MGI ID: MGI:3848061
Gene: Akt3  Location: Chr1:177020073-177258203 bp, - strand  Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149156
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsFive base pairs (GAGGA) that encode two glutamic acids (E114 and E115) in exon 4 were replaced with a lacZ-neo cassette. The absence of protein expression was confirmed by RT-PCR on placenta extracts. (J:149156)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt3 Mutation:  8 strains or lines available
References
Original:  J:149156 Chen WS, et al., Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol. 2009 Jun;29(11):3151-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory