Glis3tm1Amj
Targeted Allele Detail
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Symbol: |
Glis3tm1Amj |
Name: |
GLIS family zinc finger 3; targeted mutation 1, Anton M Jetten |
MGI ID: |
MGI:3848053 |
Synonyms: |
Glis3deltaZF5, Glis3zf |
Gene: |
Glis3 Location: Chr19:28236251-28657477 bp, - strand Genetic Position: Chr19, 22.88 cM
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Alliance: |
Glis3tm1Amj page
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Germline Transmission: |
Earliest citation of germline transmission:
J:148994
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 4, which contains the sequence coding for zinc finger 5, and parts of intron 3 and 4 were replaced with a neo cassette. Deletion of zinc finger 5 (ZF5) is predicted to disrupt DNA binding ablity and transcriptional activity of the gene. The inability of the protein produced from this allele to activate transcription of a luciferase reporter with a Glis-binding site was confirmed by cellular assay.
(J:148994)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Glis3 Mutation: |
40 strains or lines available
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Original: |
J:148994 Kang HS, et al., Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol. 2009 May;29(10):2556-69 |
All: |
4 reference(s) |
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