Nkx3-2^tm1(cre)Wez
Targeted Allele Detail

Summary

• Symbol: Nkx3-2^tm1(cre)Wez
• Name: NK3 homeobox 2; targeted mutation 1, Warren E Zimmer
• MGI ID: MGI:3848005
• Synonyms: Bapx1^cre, Bapx1-Cre, Nkx3.2^Cre
• Gene: Nkx3-2 Location: Chr5:41918826-41921563 bp, - strand Genetic Position: Chr5, 22.58 cM
• Alliance: Nkx3-2^tm1(cre)Wez page

Intestinal mesenchymal proliferation and expansion are affected in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148724
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nkx3-2^tm1(cre)Wez expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx3-2 (MGI:108015)

• Mutation details: For targeting of ES cells, a 3.6-kb fragment containing 5' flanking sequences and the first 46 codons of Nkx3-1 exon 1 served as the 5'-homology arm and a 1.6-kb fragment containing codon 112 through the end of exon 2 served as the 3'-homology arm. A PGK-NeoR cassette and Cre recombinase complementary DNA (cDNA) were inserted into exon 1 in frame with Bapx1 coding sequence. (J:148724)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx3-2 (mouse) Summary of all recombinase alleles driven by Nkx3-2. Comparative matrix view of recombinase activities Alliance mouse Nkx3-2 gene page

Expression

In Mice Carrying this Mutation:	69 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-2 Mutation: 21 strains or lines available

References

• Original: J:148724 Verzi MP, et al., Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 2009 May;136(5):1701-10
• All: 20 reference(s)