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Targeted Allele Detail
Symbol: Elavl1tm1.2Dkon
Name: ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); targeted mutation 1.2, Dimitris L Kontoyiannis
MGI ID: MGI:3847912
Synonyms: HuR-
Gene: Elavl1  Location: Chr8:4285382-4325413 bp, - strand  Genetic Position: Chr8, 2.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:149149
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre mediated recombination of the floxed Elavl1tm1Dkon allele results in removal of the ATG-containing second exon and the neo cassette. Gene inactivation was confirmed by a lack of protein in E11.5 extracts as determined by immunoblot analysis. (J:149149)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elavl1 Mutation:  26 strains or lines available
Original:  J:149149 Katsanou V, et al., The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol. 2009 May;29(10):2762-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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